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Solubility parameters may be useful to simplify very difficult phase equilibria. If you have two chiral salts, two chiral acids, an organic solvent, and CO2, you vary the pressure and temperature as well as composition ...this is a pretty difficult phase equilibrium. But we need to describe it somehow because the practice shows that it gives excellent purities if all parameters are correctly set. 

The paper shows how to reduce the number of experiments needed to find an "optimal" parameter set by using precisely calculated Hansen solubility parameters for CO2-cosolvent mixtures under pressure. 

Chiral compounds (mirror image molecules, like our hands) may have a special ratio when their atmospheric melting points are minimal. This composition is typically the limit of their recrístallization based purification too (like azeotropic composition in distillation). 

Well, we found, that the same happens under CO2 pressure and also if not only CO2 but a cosolvent is present as well. It is an exciting fundamental research result by itself (for the few researchers in this narrow field). But the method development to get these measurements done might be useful when anyone needs to understand any high-pressure multicomponent SLG phase equilibrium. 

The rGO/sulfur composite cathode prepared on a lab scale, using supercritical CO2 assisted impregnation, showed an initial discharge capacity of 1024 mAh/g at 0.1C rate.T he developed cells showed excellent performance (929 mAh/g at 1 C rate) with an ultralow decay of 0.04% per cycle even after 200 charge-discharge cycles. 

Polymer processing and application are only possible if additives are used. Some of these additives, for example phenolic antioxidants  raised concerns about the possible environmental and health hazard of their reaction products and most of the related questions have not been answered yet. Natural antioxidants from pomegranate processing byproduct is a promising alternative for specialized products. 

Cotton and starch chitosan polymer films impregnated with lemon balm (Melissa officinalis) extracts using supercritical carbon dioxide well-inhibited bovine herpesvirus.

A detailed experimental study, CO2 and CO2 + ethanol. Parameter optimization and excellent results. 

What else is more environmentally friendly, supporting the circular economy and giving the promise of a business application as well than producing a highly valuable product from a sidestream of a plant harvested for other purposes?

CBD is a very fancy component in recent years with enormous market value, and it can be extracted from the trashing residue (waste) of hemp harvested for kernel or fiber. If you are interested, read our related paper!

Aerogel research is always exciting because you only get a good aerogel if you use supercritical fluid extraction. 

Sometimes scientific results come long after the research was started. We worked on the diastereoemric salt formation based optical resolution of chlormandelic acids, using supercritical carbon dioxide as antisolvent. To understand better the optical resolution system single we graw single crystals (what a trial and error game, be patient of lucky if you try it!) and gave that samples to the colleagues at Chemical Crystallography Research Laboratory. And they found something surprising...


Understanding high-pressure phase equilibria is essential to develop any applications. Phase equilibrium studies in our labs involve extensive work on developing measurement methodology and equipment.

This section collects the application-oriented publications of our team. 

© BME, Research Group on Supercritical Fluids, 2015